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In 2016, there were 9,492 HIV cases in Estonia, the highest number in the Baltic countries.The number of new infections topped in 2001 at 1,474 cases and has been slowly falling every year since then (except 20), with 229 new cases in 2016, the lowest number since 1988. By the end of 2012 a total of 300 patients had been diagnosed with HIV-1 infection in the country, of which 66 had developed AIDS and 39 passed away as a result of the disease.Due to the availability of antiretroviral therapy, deaths from AIDS have stayed low since the introduction of protease inhibitors and combination therapy in the late 1990s.The Economist reported in January 2000 that almost 40% of "AIDS victims" are intravenous drug users.

No HIV cases were transmitted through injecting drug use.

The genetic diversity of HIV-1 in Iceland has increased significantly over time, most likely related to the increased proportion of foreign-born residents in the country from the mid-1990s.

In the most recent study investigating the prevalence and trends of transmitted drug resistance among antiretroviral-therapy naive patients in Iceland, the prevalence was found to be at moderate level (8.5%), with an evidence of decreasing prevalence of transmitted drug resistance in Iceland during 1996–2012.

Albania remains to have a low number of HIV death-related cases.

Between 1992 and until the end of 2011, Albania reported a total of 487 HIV cases.

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